Metformin Side Effects

With metformin being the most prescribed medication in the world, many new clinical trials are being conducted each year to further research the effects and benefits of metformin. It is widely known that metformin treats type-2 diabetes but it also is being tested to determine its weight loss effects and overall effect on the body.

In a recent study conducted by Genovate Biotechnology Co., LTD, diabetes patients were transferred from sulfonylurea to glyburide/metformin combination tablets. The main objective of the study was to determine if switching over to the glyburide/metformin combination tablets would be safe or if there would be adverse effects on the body. Another objective was to evaluate the overall safety of glyburide to see if it was an inferior product compared to sulfonylurea.

The study was conducted over a year in 12 different patients. Researches found that the glyburide/metformin were indeed safe to switch over from sulfonylurea. They also found that glyburide had no different major side effects then other metformin medications. It was determined that glyburide is overall a safe medication to take and was not inferior to other similar medications.

Another 31 clinical trials of metformin have been conducted regarding the effectiveness of it against placebos. In every single clinical trial, metformin came out on top over placebos. Metformin was noted by almost every single researcher to be much less painless to take by diabetes patients and that it was much more effective in controlling the body’s functions to a stable level.

In a final study conducted by a multi-center US clinic, 806 diabetes patients were tested with glyburide metformin hydrochloride. The patients’ diabetes could not be controlled by regular diet and exercise so they were considered to be patients with an absolute need of medication.  After a twenty week trial, researchers found that the combination yielded the best results to control the patients diabetes, and proved much more efficient then metformin, glyburide or a placebo by themselves. Researchers also found that the doses could be much lower if a combination of glyburide metformin hydrochloride was taken.

Research is going to be continued on the effects of glyburide and metformin for many years to come. Research seems to point towards the two medications to be the best form of treatment of diabetes. Currently, there are three open clinical trials on the medications to determine just how effective the combination is in regards to weight loss. It is currently believed that while the combination is no replacement for a healthy diet and exercise, it may provide the body with the extra support it needs to get down to a healthy weight and to function as best as it possibly can. As much research is completed regarding glyburide and metformin, this page will be updated so that the most up to date material can be given.